De-epithelization

De-epithelization refers to the removal or loss of epithelial cells, the cells that form a protective layer on surfaces of the body, such as the skin, lining of the digestive tract, and the cornea of the eye. This process can occur due to various factors including injury, inflammation, infection, or disease. It often involves the disruption of cellular junctions and subsequent detachment or destruction of the epithelial layer, leading to exposure of underlying tissues and potentially impaired function.

De-epithelization meaning with examples

• A severe chemical burn resulted in significant de-epithelization of the skin, causing extensive tissue damage and requiring prolonged wound care. The affected areas lost their protective barrier, increasing vulnerability to infection and requiring intensive medical interventions. This was considered critical.
• Chronic friction from ill-fitting dentures caused de-epithelization of the oral mucosa in several areas, creating painful sores. The continuous abrasion led to the breakdown of the epithelial lining, making it difficult for the patient to eat and causing considerable discomfort. Replacement dentures were required.
• Following a corneal abrasion, the patient's eye exhibited de-epithelization, exposing the corneal stroma. This caused significant pain, blurry vision, and sensitivity to light. The wound healing process was carefully monitored to prevent complications. Timely intervention with lubricants aided in the healing.
• In some cases of inflammatory bowel disease (IBD), de-epithelization of the intestinal lining occurs, leading to ulceration and bleeding. This damage impairs the absorption of nutrients and can cause chronic abdominal pain and diarrhea. Immunosuppressants reduce the damage.
• The surgical procedure inadvertently caused a small degree of de-epithelization in the targeted area, where cell removal was intended. The microscopic changes caused by de-epithelization were planned and were considered part of the medical process. It was necessary and had an expected outcome.