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Electrophilic

Electrophilic describes a chemical species that is attracted to a region of negative charge and is capable of accepting an electron pair to form a covalent bond. These species are electron-deficient, meaning they have a partial or full positive charge or an incomplete octet. Their reactivity stems from their inherent 'love' for electrons, making them crucial in various chemical reactions, especially those involving substitution and addition. The electrophilic nature is often influenced by the electronic structure and the presence of electron-withdrawing groups in the molecule. Electrophiles play a significant role in organic chemistry, biochemistry, and various industrial processes.

Electrophilic meaning with examples

  • In a Friedel-Crafts acylation, the acylium ion (RCO+) acts as a strong electrophile. It is attracted to the electron-rich pi system of the benzene ring and initiates the electrophilic aromatic substitution, ultimately leading to the formation of a ketone.
  • During halogenation of an alkene, a halogen molecule (e.g., Br2) acts as an electrophile. The bromine molecule interacts with the double bond, leading to the formation of a cyclic bromonium ion intermediate, which then undergoes further reaction.
  • Protonation of an alcohol (ROH) by an acid forms the oxonium ion (R-O+H2), which is an electrophilic species due to the positive charge on the oxygen atom. This makes the carbon atom bonded to the oxygen more susceptible to nucleophilic attack.
  • In electrophilic addition to alkenes, the electrophile attacks the pi electrons of the double bond, forming a carbocation intermediate. This is a common reaction to create C-C bonds and form a new sigma bond.
  • Carbonyl compounds, like aldehydes and ketones, are susceptible to nucleophilic attack at their carbonyl carbon, which has a partial positive charge and thus is electrophilic. This electrophilic character enables them to react with Grignard reagents.

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