Immunogenic

Immunogenic refers to the ability of a substance, typically a molecule or antigen, to provoke an immune response within an organism. This response can range from the production of antibodies and the activation of immune cells like T-cells and B-cells, leading to acquired immunity. The degree of immunogenicity varies depending on factors such as the foreignness, size, complexity, and the presence of adjuvants. A highly immunogenic substance is likely to induce a strong and effective immune response, while a weakly immunogenic substance might elicit a negligible or even no immune response. Understanding immunogenicity is crucial in vaccine development, where the goal is to elicit a protective immune response against specific pathogens.

Immunogenic meaning with examples

• The novel vaccine candidate demonstrated significant immunogenic properties in preclinical trials, with a robust antibody response observed in vaccinated animals. This suggested the vaccine's potential to protect against the target virus. The research team was excited by the initial findings and planned further investigations into long-term immune memory and efficacy.
• Researchers are exploring ways to enhance the immunogenic potential of cancer vaccines by incorporating adjuvants to amplify the immune response. They hoped to create a stronger, more effective response to cancer cells by using highly immunogenic molecules with the cancer cells to improve the effectiveness of their vaccines.
• The modified protein displayed greater immunogenicity compared to the original version, resulting in increased antibody titers and improved protection against a bacterial infection. This outcome was a huge step forward in helping fight the infection and saving the lives of many.
• In the context of organ transplantation, the immunogenic nature of donor tissues presents challenges, as the recipient's immune system may recognize them as foreign and mount an attack. Immunosuppressant drugs are used to prevent rejection by suppressing the immune response.
• Careful selection of antigens is crucial in vaccine design, aiming to include highly immunogenic components that can trigger a broad and durable immune response. This will ensure the vaccine is both safe and effective against targeted diseases by building a robust immune system.