Non-progression

Non-progression refers to the state or condition where a disease or condition remains stable and does not worsen over a specific period. It signifies a lack of advancement or worsening in the severity of the condition, often used in medical contexts to describe the absence of tumor growth, disease spread, or functional decline. This term is crucial for evaluating treatment efficacy and patient prognosis. non-progression doesn't necessarily mean improvement or complete remission; rather, it indicates the disease is controlled or contained, preventing further deterioration and is a positive indication with cancer management. It’s commonly contrasted with disease progression, and is often used in the context of clinical trials.

Non-progression meaning with examples

• After six months of chemotherapy, the oncologist reported non-progression of the patient's lung cancer. The tumors remained the same size, indicating the treatment was effectively holding the disease at bay, allowing further treatment options to be discussed with the patient in the future.
• During the clinical trial, the primary endpoint was progression-free survival; a patient with non-progression for a year was considered a success. This outcome provided valuable data regarding the treatment's ability to stabilize the disease in a significant number of the study’s patients.
• The patient’s MRI scans revealed non-progression of the brain tumor, providing a sense of relief. This stability meant that the current treatment regimen was providing at least some benefit and was a positive sign that the patient was responding to the treatment.
• Monitoring the patient’s chronic kidney disease revealed a period of non-progression, allowing the healthcare team to focus on maintaining the patient’s current kidney function and potentially avoid dialysis for some time.