Pericellular

Relating to or situated around a cell, especially a nerve cell, and encompassing the immediate extracellular environment. This term describes the region directly surrounding a cell, including the substances and structures that interact closely with the cell's surface. It signifies the microenvironment in which a cell functions and is influenced by factors like the extracellular matrix, neighboring cells, and the composition of surrounding fluids. The pericellular space plays a critical role in cellular communication, nutrient transport, and waste removal, directly affecting cell behavior and survival. The pericellular environment is essential for maintaining cell homeostasis and facilitating cellular processes like growth, differentiation, and apoptosis.

Pericellular meaning with examples

• In neuronal studies, the pericellular glial cells surrounding the neuron's soma have been observed actively regulating synaptic transmission. The study showed how these glial cells helped maintain a stable pericellular ionic concentration, crucial for efficient neuronal signaling. This pericellular support highlights the complex interplay between neurons and their surrounding glial environment.
• Examination of cancerous tissue revealed a unique pericellular matrix composition surrounding tumor cells compared to healthy cells. This altered pericellular environment was found to promote tumor cell proliferation and invasion. Further investigation highlighted the role of specific proteins within the pericellular space in facilitating metastasis.
• Drug delivery strategies often focus on modifying drug molecules to ensure effective pericellular penetration. Specifically, nanocarriers designed to target the pericellular space can improve drug bioavailability and efficacy within the tissue. This targeted delivery helps to increase the localized concentration of the therapeutic agent and minimize off-target effects.
• The study of cartilage examined the pericellular region which revealed a distinctive structural organization affecting the chondrocytes. The pericellular matrix, including collagen fibers and proteoglycans, was found to be integral for maintaining the tissue's mechanical properties and load-bearing capacity, crucial for joint function.