Proteomics-based

Proteomics-based refers to methodologies, analyses, or research predicated on the study of the proteome, the complete set of proteins expressed by an organism, cell, or tissue. It involves identifying, quantifying, and characterizing proteins and their interactions to understand biological processes, disease mechanisms, and drug responses. This approach utilizes various techniques such as mass spectrometry, protein microarrays, and bioinformatics to analyze protein expression and modifications, often providing a comprehensive and unbiased view of cellular function that can lead to biomarkers of specific diseases. Data obtained can inform the development of new treatments and diagnostics. It enables the study of cellular function in ways that genomics cannot alone.

Proteomics-based meaning with examples

• The research team employed a proteomics-based approach to analyze the protein composition of cancer cells. Using mass spectrometry, they identified several proteins that were differentially expressed in cancerous tissues compared to normal tissues. These findings highlighted potential therapeutic targets and biomarkers. Furthermore, proteomics-based studies provide more understanding of the cellular environment and how its changed by disease.
• Development of personalized medicine strategies often involves proteomics-based analysis to determine an individual's protein profile. By examining protein expression patterns, physicians can tailor treatments to maximize efficacy and minimize side effects. It is helpful to evaluate drug response and the overall health profile of patients and determine specific medications and dosages.
• Researchers utilized a proteomics-based investigation to understand the mechanisms of Alzheimer's disease. They analyzed brain tissue samples and identified changes in protein aggregation and post-translational modifications. The proteomic analysis uncovered potential novel therapeutic targets and can indicate the progression of the disease. This allowed a greater and more precise understanding of the disease.
• Drug discovery efforts increasingly incorporate proteomics-based techniques to identify potential drug targets. By studying how drugs interact with cellular proteins, scientists can determine their mechanisms of action and predict their efficacy. High-throughput proteomic analyses can quickly screen for protein-drug interactions and potential side effects of new medications.