Solvent-incompatible

Describing a substance, material, or component that will not readily mix with, dissolve in, or be stable in the presence of a specific solvent, leading to undesirable reactions such as precipitation, degradation, swelling, or a phase separation. This incompatibility can arise from differences in polarity, intermolecular forces, or chemical reactivity between the material and the solvent. Careful consideration of solvent compatibility is crucial in various applications, from chemical synthesis and coatings to pharmaceutical formulations and storage of materials.

Solvent-incompatible meaning with examples

• The new epoxy resin was found to be solvent-incompatible with acetone. When exposed to the solvent, the resin underwent significant swelling and lost its structural integrity, rendering it unsuitable for the intended application of creating a durable coating. Alternative solvents needed to be tested before its application.
• During the cleaning process, the technician discovered the paint was solvent-incompatible with the chosen cleaner. This caused the paint to streak and smear, which damaged the artwork. Testing a more inert cleaner was recommended to safely eliminate the paint.
• In the manufacturing of a pharmaceutical suspension, the active ingredient proved solvent-incompatible with the chosen vehicle. The drug precipitated out of the solution over time, reducing its bioavailability and shelf life. Formulation research with alternative solvents and vehicles were imperative.
• The lab's new filter paper was solvent-incompatible with the organic solvent being used to separate the mixture, causing the filter paper to degrade and fall apart. A specialized filter paper would be necessary that will withstand the solvent.