Thrombogenic

Thrombogenic describes something that promotes or induces the formation of a thrombus, which is a blood clot. This clotting process can occur within blood vessels, leading to potential blockages and disruptions in blood flow. Materials, surfaces, or conditions classified as thrombogenic have a tendency to trigger the coagulation cascade. The degree of thrombogenicity varies depending on the specific factors involved. Understanding thrombogenicity is critical in various medical contexts, including cardiovascular health, the design of medical devices, and the use of therapeutic interventions. This awareness helps mitigate the risks associated with unwanted clot formation.

Thrombogenic meaning with examples

• The rough surface of the artificial heart valve was found to be highly thrombogenic, contributing to the formation of blood clots that led to serious complications in patients. This prompted modifications to the valve design to reduce its thrombogenicity. Further studies of biocompatible materials aimed to minimize this effect and improve patient outcomes.
• Research focused on identifying less thrombogenic materials for vascular grafts to prevent graft failure due to clot formation. The goal was to create grafts that the body readily accepts without triggering the coagulation cascade, ensuring long-term patency of the vessels. Different coatings were also tested.
• Elevated levels of certain clotting factors in the blood can make the blood itself more thrombogenic, increasing the risk of deep vein thrombosis. Lifestyle changes and medication may be required to reduce the risk for at-risk patients, focusing on the underlying cause.
• The study investigated the thrombogenic properties of various catheter materials to determine which ones posed the lowest risk of causing catheter-related thrombosis. Biocompatibility and surface characteristics were considered essential elements.
• Certain surgical procedures, particularly those involving the use of foreign materials, have the potential to be thrombogenic, requiring careful attention to surgical technique and the administration of antithrombotic drugs to prevent complications. Careful monitoring is also essential.