Xeroderma

Xeroderma, also known as xeroderma pigmentosum (XP), is a rare genetic disorder characterized by extreme sensitivity to ultraviolet (UV) light. It is caused by defects in the nucleotide excision repair (NER) pathway, which normally repairs DNA damage caused by UV radiation. Individuals with xeroderma pigmentosum have a severely impaired ability to repair this damage, leading to a significant increase in the risk of skin cancer, as well as other health problems. The condition manifests with freckle-like spots, sun sensitivity, and premature aging. Early diagnosis and strict sun protection are crucial for managing this condition.

Xeroderma meaning with examples

• The dermatologist diagnosed the child with xeroderma after observing the skin's excessive sensitivity to sunlight and the development of numerous freckles and spots. Regular follow-ups and strict avoidance of UV exposure are vital to prevent complications.
• A patient with xeroderma must be diligent in using broad-spectrum sunscreens, wearing protective clothing, and seeking shade to minimize exposure to UV radiation. This proactive approach is crucial in managing the condition and improving the patient's quality of life.
• The genetic testing confirmed a diagnosis of xeroderma, revealing mutations that impair the DNA repair mechanisms. Further investigations were done, and it was explained how the genetic makeup resulted in sun sensitivities to UV light.
• Due to her xeroderma, she developed several basal cell carcinomas at a young age, underscoring the aggressive nature of the disease and the need for early detection and treatment to manage the risk of skin cancer.