Desolvate

To separate or remove a solvent from a substance, typically a solute, or the process by which a solvated ion or molecule releases its associated solvent molecules and returns to a more isolated or less interacting state. This can occur through various methods like heating, evaporation, or changes in pressure, affecting the solubility and chemical properties of the substance. It's the opposite of solvation, where a solute becomes surrounded by solvent molecules. The process often modifies the interaction between solute particles and influences physical states like crystallization.

Desolvate meaning with examples

• When heating the salt solution, the water desolvates from the sodium chloride molecules, leading to the salt's recrystallization. The high temperature provided the energy required for the separation. The resulting dry salt crystals show the effectiveness of desolvation, leaving them ready for separate uses.
• During protein folding studies, removing the water molecules that surround the protein can allow it to adopt its most stable, folded state. These desolvated protein structures can now interact directly, offering crucial insight into their function. This step showcases a crucial element in protein conformation.
• In a freeze-drying process, water is sublimated from a frozen sample, causing the solute to desolvate. The dry product is shelf-stable because there are no water molecules interacting with it. This offers a technique in the lab that provides product longevity and long term storage capabilities.
• A scientist could use a vacuum to desolvate a substance by lowering the pressure, allowing the solvent to evaporate at a lower temperature. This is used when dealing with heat-sensitive compounds. Desolvation in a vacuum creates a high-purity product.
• A pharmaceutical company may need to desolvate a drug solution to create a solid form suitable for pills. By removing the solvent, the active drug particles can aggregate. This solid state enhances shelf life and ease of administration through careful control of the process.